Expression of Transient Receptor Potential Channels 3 Trpc1 and Trpv4 in Venoatrial Endocardium of the Rat Heart
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منابع مشابه
Expression of transient receptor potential channels TRPC1 and TRPV4 in venoatrial endocardium of the rat heart
The atrial volume receptor reflex arc serves to regulate plasma volume. Atrial volume receptors located in the endocardium of the atrial wall undergo mechanical deformation as blood is returned to the atria of the heart. The mechanosensitive channel(s) responsible for regulating plasma volume remain to be determined. Here we report that the TRP channel family members TRPC1 and TRPV4 were expres...
متن کاملExpression of store-operated Ca2+ entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle.
Chronic hypoxia causes remodeling and alters contractile responses in both pulmonary arteries and pulmonary veins. Although pulmonary arteries have been studied extensively in these disorders, the mechanisms by which pulmonary veins respond to hypoxia and whether these responses contribute to chronic hypoxic pulmonary hypertension remain poorly understood. In pulmonary arterial smooth muscle, w...
متن کاملDepletion of intracellular Ca2+ stores stimulates the translocation of vanilloid transient receptor potential 4-c1 heteromeric channels to the plasma membrane.
OBJECTIVE To examine the effect of Ca(2+) store depletion on the translocation of vanilloid transient receptor potential (TRPV) 4-C1 heteromeric channels to the plasma membrane. METHODS AND RESULTS Vesicular trafficking is a key mechanism for controlling the surface expression of TRP channels in the plasma membrane, where they perform their function. TRP channels in vivo are often composed of...
متن کاملExpression of store-operated Ca entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle
Peng G, Lu W, Li X, Chen Y, Zhong N, Ran P, Wang J. Expression of store-operated Ca entry and transient receptor potential canonical and vanilloid-related proteins in rat distal pulmonary venous smooth muscle. Am J Physiol Lung Cell Mol Physiol 299: L621–L630, 2010. First published August 6, 2010; doi:10.1152/ajplung.00176.2009.—Chronic hypoxia causes remodeling and alters contractile responses...
متن کاملTRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization.
The transient receptor potential vanilloid 4 (TRPV4) contributes to mechanical hyperalgesia of diverse etiologies, presumably as part of a mechanoreceptor signaling complex (Alessandri-Haber et al., 2008). To investigate the hypothesis that a functional interaction between TRPV4 and stretch-activated ion channels (SACs) is involved in this mechanical transduction mechanism, we used a selective ...
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تاریخ انتشار 2016